Our results have indeed shown that clemastine modulates LC3-II, SQSTM1/p62 and mTOR in the NSC34 SOD1-G93A motoneuron cells in a time-dependent manner, in parallel with the different effects exerted by short and long treatment in ALS mice, and thus sustaining at least in part our hypothesis. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.