SQSTM1 and amyotrophic lateral sclerosis: Our results have indeed shown that clemastine modulates LC3-II, SQSTM1/p62 and mTOR in the NSC34 SOD1-G93A motoneuron cells in a time-dependent manner, in parallel with the different effects exerted by short and long treatment in ALS mice, and thus sustaining at least in part our hypothesis.