SQSTM1 and amyotrophic lateral sclerosis: Since it is known that SQSTM1/p62 autophagy substrate accumulates in the lumbar spinal cord of ALS mice during the disease [30], we measured the level of SQSTM1/p62 protein and demonstrated that it was significantly down-regulated in clemastine-treated mice respect to vehicle (6.8 ± 1.3 in vehicle-treated mice and 3.8 ± 1.2 in clemastine-treated mice, respect to WT, Fig. 3d).