Altered macroautophagy is reported in the spinal cord of SOD1 mutant mice [7] and autophagy overexpression is proved in motor neurons of ALS mice by in vivo optical imaging [8]; moreover, inefficient autophagosome-lysosome fusion is reported in ALS patients [9, 10] to the point that a strategy in modulating autophagic flux may have a promise in ALS treatment [11, 12]. This evidence concerns the gene SOD1 and amyotrophic lateral sclerosis.