EGLN3 and neoplasm: To verify the status of hypoxia in our Myc tumor model, a hypoxia reporter transgenic line Tg(phd3:EGFP) was crossed with TO(Myc) and the double transgenic larvae were induced with Dox for 4 days from 3 dpf and imaged under a fluorescent microscope, where the hypoxia status was indicated by the intensity of green fluorescence.