Conversely, to further understand the role of RPB2 in NET formation, we transiently knocked down RBP2 in the NET cell lines H727 (derived from lung carcinoid NET) and QGP-1 (derived from somatostatinoma pancreatic NET), which both have high levels of RBP2. This evidence concerns the gene RBP2 and pancreatic neuroendocrine tumor.