RBP2 and pancreatic neuroendocrine tumor: In non-NETs, RBP2 directly activates cell growth through its demethylase activity by decreasing the expression of cell cycle inhibitors, and indirectly affects cell cycle arrest by forming complexes with multiple proteins to regulate transcriptional activation.8, 11, 15, 16 A recent report demonstrates that inhibiting RBP2 production in a pancreatic NET mouse model halts tumor formation;17 however, this study did not demonstrate a causative role for or a mechanistic impact of RBP2 overexpression.