RHD and neoplasm: No difference in tumor growth was observed between Rh30 wt and Rh30 fur, whereas decreased furin activity resulted in a clear delay in tumor growth (Fig 3A); Rh30 pdx, Rh30 shFA and Rh30 shFE tumors took approximately 1.5-times longer to reach a size of 500 mm3 compared to Rh30 wt (Fig 3A).