FURIN and neoplasm: To decipher the furin substrates involved in tumor growth, migration and invasion in RMS cells, we examined by immunoblotting the maturation status of IGF1Rβ, VEGF-C, PDGF-BB and MT1-MMP in Rh30 wt and RD wt cells upon inhibition of furin activity by the PC inhibitor CMK (Fig 5A).