In R. typhi-infected CB17 SCID mice numbers of CD11b+GR1hi neutrophils and CD11b+GR1low MΦ/monocytes steadily increased during the course of infection beginning on day 3 and resulting in an approximately 30-fold increase of MΦ/monocytes (control: 2.5×105, R. typhi-infected: 8.2×106; Fig 2C, left) and 50-fold increase of neutrophils immediately prior to death (control: 1.18×105, R. typhi-infected: 6.74×106; Fig 2C, right). This evidence concerns the gene ITGAM and infection.