In BALB/c wild-type mice numbers of CD11b+GR1low MΦ/monocytes remained unaltered during the course of infection (Fig 2C, left) while numbers of CD11b+GR1hi neutrophils were slightly enhanced early in infection on day 3 (control: 7.22×105, R. typhi-infected: 1.73×106) and returned to basal counts until day 7 (Fig 2C, right). This evidence concerns the gene ITGAM and infection.