Therefore, the changes induced in hepatoma cells by Pdrg1 downregulation seem to follow an opposite pattern than those exhibited by Mat1a-/- or Gnmt-/- livers with hepatic damage (esteatosis, hepatocellular carcinoma), which show induced or normal lipogenesis, respectively [45, 66–71]. This evidence concerns the gene PDRG1 and hepatocellular carcinoma.