First, conditioning on HLA-B*51 the statistical significance of the class I signals was considerably reduced being HLA-B*57 the highest peak: (P = 1.02E-05, OR = 2.80, 95% CI = 1.77–4.43), which confirmed the major role that this HLA molecule seems to have in the immunopathological mechanisms leading to BD development. Here, HLA-B is linked to Behcet disease.