The phenotype that we observed in csMed1-/- mouse heart mirrors in many respects to that observed for mice that carry a zeitgeist recessive N-ethyl-N-nitrosourea (ENU)-induced missense mutation in Med30 gene [32], including DCM, myocardial fibrosis, echocardiographic results, and changes in gene expression patterns. This evidence concerns the gene MED30 and familial dilated cardiomyopathy.