The CD4/CD8 ratio did not add supplementary prognostic information when added to the CD4+ cell count (data not shown for bacterial infections and cardiovascular events), except for the prediction of the first non-AIDS cancer for which both CD4+ cell count < 100/mm3 and CD4/CD8 < 0.5 were independently associated with a higher risk of event and the model containing only the CD4/CD8 ratio was associated with the higher likelihood with an HR of 2.13 for CD4/CD8 < 0.5 vs ≥ 0.5 (95% CI = 0.31–0.90) (Table 4). The gene discussed is CD8A; the disease is AIDS.