Interestingly, treatment of SMS-KCNR neuroblastoma (25.0 μg/mL) cancer cells for 18 h with cranberry proanthocyanidins also resulted in inactivation of PI3K/AKT/mTOR signaling pathways and at concentrations lower than those necessary for similar effects in esophageal adenocarcinoma (50.0 μg/mL) cancer cells [39,44]. This evidence concerns the gene PIK3CA and esophageal adenocarcinoma.