Furthermore, cranberry proanthocyanidins (25.0 μg/mL) increase mitogen-activated protein kinase (MAPK) signaling and decrease PI3K/AKT signaling in prostate cancer cells, suggesting a common cell death mechanism with esophageal adenocarcinoma, ovarian and neuroblastoma cancer cells [52]. Here, AKT1 is linked to Familial prostate cancer.