Kaposi’s sarcoma-associated herpesvirus (KSHV) latent protein, latency-associated nuclear antigen (LANA), was also found to bind directly to Sp1 in KSHV-infected body-cavity-based lymphoma (BCBL) cells and enhance the binding of Sp1 to its cognate binding sites in the hTERT proximal promoter [165,166]. Here, SP1 is linked to primary effusion lymphoma.