MYC and hepatocellular carcinoma: Despite the strong evidences brought forth by the various studies above regarding the key role c-Myc plays in the modulation of hTERT expression and telomerase activity, several studies involving the use of primary tumor samples have proven the lack of correlation between c-Myc expression and hTERT mRNA levels, specifically in hepatocellular carcinoma and breast carcinoma tissue samples [208,209].