In addition, SET and MYND Domain-Containing Protein 3 (SMYD3) knockdown in colorectal carcinoma and hepatocellular carcinoma cells was found to diminish the occupancy of c-Myc at hTERT promoter via reduction in H3K4 trimethylation and histone H3 acetylation. This evidence concerns the gene SMYD3 and hepatocellular carcinoma.