The P protein was shown to specifically target the interferon-beta (Ifn-β), myxovirus resistance protein 1 (Mx1) and 2′-5′-oligoadenylate synthetase 1 (Oas1) genes, resulting in the decreased expression of these genes that are important in innate responses against viral infections (Figure 1) [30,34]. The gene discussed is IFNB1; the disease is viral infectious disease.