Additionally, increased expression of miR-181b has been observed in TAM-resistant breast cancer [192,194], miR-101 promotes estrogen independent growth and causes TAM resistance in ERα-positive breast cancer cells [195], up-regulated miR-301 increases proliferation, migration, invasion, and tumor formation, and also has been associated with TAM resistance in MCF7 cells [196] and miRNA-519a confers TAM resistance in MCF7 cells through regulation of the cell cycle and apoptosis [197]. The gene discussed is ESR1; the disease is breast cancer.