TNF and hepatocellular carcinoma: In fact, in human hepatoma Huh7 cells, it was demonstrated that IL-8 and several other inflammatory genes all contain the AU rich elements (AREs) in the 3’-untranslated region (3’-UTR), which potentially plays an important role to regulate the mRNA stability; CHX together with TNF-a were noted to perform a superinduction effect of mRNAs of IL-8 and these inflammatory genes [64].