CDKN1A and cervical carcinoma: Several studies have investigated the anti-carcinogenic effects of this compound, pointing out that apigenin inhibits the growth of cervical cancer cell lines (CaSki, HeLa, and C33A) that cause G1 phase growth arrest through the induction of apoptosis, which was p53 dependent and associated with a marked increase in the expression of p21/WAF1 protein and with the induction of Fas/APO-1 and caspase-3 expression.