ALB and glomerulosclerosis: In a study by Jackson et al. [54], male offspring of rats fed a high fat, high fructose diet for 6 weeks prior to pregnancy, throughout gestation and lactation, had normal blood pressure and glomerular filtration rate (GFR) yet increased urinary albumin excretion, glomerulosclerosis and tubulointerstitial fibrosis by 4 months of age.