Our findings of weaker associations with CRP and no associations with other pain are consistent with previous NSHD findings11,12 but not findings from some other studies.18 Hotopf et al12 reported no associations between any serious physical illness before age 15 and chest pain or multiple medically unexplained physical symptoms (including these health complaints: rheumatism and arthritis, headache, backache and sciatica, abdominal pain, chest pain, and dizziness)11 at age 36 years in the NSHD. The gene discussed is CRP; the disease is Arthritis.