Moreover, further enhancing activation of ALDH2 expression of low doses of ethanol for 8 weeks in diabetic rats, accompanied with the high-expression of ALDH2, p-JNK/JNK were decreased in contrast to diabetes rats, which suggested activation of ALDH2 expression might be associated with downregulating the JNK signaling pathway to relieve myocardial fibrosis and myocardial injuries. Here, MAPK8 is linked to diabetes mellitus.