So in this study, we mimic diabetes model by intraperitoneal injection of streptozotocin (STZ) in combination with low-dose ethanol; the purpose of the present study is as follows: (1) to investigate the mechanism of low-dose ethanol which alleviates myocardial fibrosis in diabetic cardiomyopathy; (2) to clarify whether low-dose ethanol mediated protection is associated with downregulating the JNK signaling pathway. This evidence concerns the gene MAPK8 and diabetes mellitus.