It is worthwhile to note that, in our experiment, we found that, with the progression of diabetes, the expression of myocardial ALDH2 at mRNA level was decreased and the ratio of p-JNK/JNK at protein level was increased, which suggested ALDH2 and JNK signaling pathway both participated in the occurrence and development of diabetic cardiomyopathy. This evidence concerns the gene MAPK8 and diabetes mellitus.