MAPK8 and diabetic cardiomyopathy: It is worthwhile to note that, in our experiment, we found that, with the progression of diabetes, the expression of myocardial ALDH2 at mRNA level was decreased and the ratio of p-JNK/JNK at protein level was increased, which suggested ALDH2 and JNK signaling pathway both participated in the occurrence and development of diabetic cardiomyopathy.