LEP and Alzheimer disease: Adipokine dysregulation has been correlated with AD, producing changes in proinflammatory adipokines such as an increase in TNF-α, interleukin 6 (IL-6), and leptin; a decrease in anti-inflammatory adipokines such as adiponectin; decreased brain derived neurotrophic factor (BDNF); and increased plasminogen activator inhibitor-1 (PAI-1) and angiotensin (AGT) [81, 82].