DUX4 and facioscapulohumeral muscular dystrophy: Next-generation sequencing of FSHD myoblasts reported several additionally dysregulated microRNAs when compared with unaffected patient myoblasts [65] (Table 1).Additionally, a long-noncoding RNA (lncRNA)DBE-T has been implicated in the transcriptional activation of DUX4, and may also play a significant role in the promotion of the FSHD disease pathology [66].