Also, the levels of expression of the well-known pro-angiogenic molecules (VEGF and b-FGF) and pro-invasive molecules (MMP-2 and MMP-9) were highly inhibited following combination of EWS shRNA plasmid transfection and TFL treatment in Ewing’s sarcoma xenografts. The gene discussed is ZC3H12D; the disease is Ewing sarcoma.