In Ewing’s sarcoma, the chomosomal translocation t(11; 22)(q24; q12) generates a fusion of the 5’ transcriptional activation domain of EWS gene with the 3’ DNA-binding domain of Friend leukemia integration 1 (FLI1) gene resulting in the fusion oncoprotein EWS-FLI1, which acts as an aberrant transcriptional activator with strong transforming capabilities [4]. This evidence concerns the gene EWSR1 and Ewing sarcoma.