Glutathione peroxidase 4 (Gpx4) could function as a unique antioxidant enzyme to inhibit lipid peroxidation and play a vital role in the homeostatic survival of CD8+ T cells and in both CD4+ and CD8+ T cell expansion upon TCR triggering in response to infection by preventing membrane lipid peroxidation and ferroptosis [100]. The gene discussed is CD8A; the disease is infection.