Finally, Pr(DKK1 - Off |Sample - Tumor, Me - M) being high is the fraction of number of 0’s in thetumorous sample (d×(1−p)) and the sum of total number oftumorous samples and number of 0’s in the normal samples, i.e., the methylatedgene expression values in normal samples (D). This evidence concerns the gene DKK1 and neoplasm.