Similarly, Pr(DKK1 - On |Sample - Tumor, Me - UM) being low is the fraction of number of 1’s in thetumorous sample (b×(1−p)) and the sum of total number oftumorous samples and number of 1’s in the normal samples, i.e., thenon-methylated gene expression values in normal samples (B). The gene discussed is DKK1; the disease is neoplasm.