RTN4 and Stroke: Following neutralizing NogoA antibody delivery, massive overactivation of the small Rho GTPases Rac1 and RhoB was noticed when the antibody was administered prior to stroke, the former of which overactivated the stress kinases p38 and Jun kinase-1/2 (JNK-1/2) thus activating cell death pathways (Kilic et al., 2010).