They also affect risk 6 and age at onset 7 of the amnestic phenotype of dementia due to Alzheimer disease, as well as cognitive decline 5: rs1800764 is located at ∼0.2 kb from the transcription start site in the promoter of ACE in 17q23, while rs4291 is at ∼3.8 kb from the same site 6. Here, ACE is linked to Alzheimer disease.