Interestingly, Diaz-Moralli et al. discovered that a significant association of TKTL1 expression with lymph-node involvement while a significant decrease of TKTL1 expression associated with metastasis40, similar appearance has been observed in mutation of ras in CRC: the incidence of mutation increases from 7% to 60% starting early till late carcinomas, but decreases to 45% in invasive phrase, indicating an possibility that TKTL1 contributed in cell aggressiveness but not in metastasized cells like ras mutation41, 42. This evidence concerns the gene TKTL1 and carcinoma.