NOX4 and neoplasm: miR-23b inhibited the generation of reactive oxygen species by inhibiting the expression of NOX4, a member of the NADPH oxidase family28, it was also found to trigger cancer-promoting effects by inhibiting the expression of apoptosis antigen 1 (FAS) and the tumor suppression gene, phosphatase and tensin homolog (PTEN), in lymphoma and kidney cancer29, 30.