The significant activation of PPARγ in WAT may be important for the observed hepatoprotective effects, because PPARγ activation in liver could cause detrimental effects: Recent knock-out studies have shown that targeted PPARγ deletion in hepatocytes or macrophages protected mice against high-fat induced steatosis21, while deletion of PPARγ in adipose tissues increased liver steatosis upon high-fat feeding22. The gene discussed is PPARG; the disease is fatty liver disease.