As shown in the Fig. 3, the levels of IFN-γ, TNF-γ, IL-1β, IL-12p70 and IL-6, but not IL-10, were significantly higher in IL-21RKO mice than those in C57BL/6 mice on day 5 after DSS-induced colitis (*P < 0.05). Here, IL10 is linked to colitis.