Genes encoding exosome complex components are linked to pathologies including cancer (DIS3) (Chapman et al., 2011), immune disorders (EXOSC9 and EXOSC10) (Allmang et al., 1999b) and congenital neurological disorders (EXOSC3 and EXOSC8) (Boczonadi et al., 2014; Rudnik-Schoneborn et al., 2013; Wan et al., 2012). Here, EXOSC3 is linked to cancer.