The magnitude of this risk following exclusion of those with a history of CVD (n = 1533) and cancer (n = 1410) and then adjustment of other confounders (model C: HR 1.40, 95 % CI 1.25–1.56) was attenuated by thyroid function (model E: HR 1.26, 95 % CI 1.10–1.45) and less so by CRP (model F: HR 1.39, 95 % CI 1.21–1.60). The gene discussed is CRP; the disease is cancer.