Taken together, while chemokine receptor regulation in response to stimulation with α-IgM and α-IgD was reduced in CLL, with compensation when using stronger BCR stimulation by immobilised antigens, differential regulation of CXCL12- and CCR7-mediated chemotaxis was observed after IgM and IgD activation. The gene discussed is CCR7; the disease is B-cell chronic lymphocytic leukemia.