The number of epidemiological studies reporting results about the COX-2 inhibitors’ effect on breast cancer or about NSAIDs’ effect on different types of breast cancer (i.e.: ER+, PR+, Human epidermal growth factor receptor [HER2] +, triple negative) is still small and further studies are needed in order to clarify the specific effect of NSAID groups on different types of breast cancer [8, 10–12]. This evidence concerns the gene ESR1 and breast carcinoma.