The lower PGC1α mRNA expression in EAT from CAD patients with DM2 might contribute to the lower clearance of circulating triglycerides, possibly due to reduced PGC1α and UCP1-mediated β-oxidation of fatty acids in EAT, which may be accompanied by a suppression of adipocyte fatty acid uptake [21, 22]. This evidence concerns the gene PPARGC1A and coronary artery disorder.