PGC1α and UCP1 mRNAs in EAT were significantly lower in the CAD-DM2 patients compared with the CAD-NDM2 patients (P = 0.027 and P = 0.038, respectively) and NCAD patients (p = 0.031 and p = 0.045, respectively) (Fig. 1a, b). The gene discussed is UCP1; the disease is coronary artery disorder.