As WSB1 is a positive regulator of HIF-1 and miR-592 is a negative regulator of WSB-1, investigators have postulated that miR-592 is a negative mediator of the Warburg effect in HCC cells, and that the HIF-1/WSB1/miR-592 regulatory axis may be a new point of treatment for HCC cases [16]. Here, WSB1 is linked to hepatocellular carcinoma.