Loss of cell adhesion via deregulation of CD44, CLDN4, and CLDN6, followed by increased migration and invasive capabilities through upregulation of MMP2 describes a pattern consistent with localized ovarian cancer cells transforming into metastasizing PC cells, and expands previous data showing that deregulation of proliferation and cell adhesion is a feature of malignant transformation in ovarian and peritoneal cancer [10–13, 19, 28]. The gene discussed is CLDN4; the disease is ovarian cancer.