Also, approaches toward tumor therapy and vaccination using GPI-anchored variants of the costimulatory molecule, B7.1 (47, 48), the cytokines, interleukin (IL)2 (49, 50) and IL12 (51–53), granulocyte/macrophage-colony stimulating factor (GM-CSF) (19), the human epidermal growth factor (EGF) receptor 2 (HER2) tumor antigen (36), and the intercellular adhesion molecule, (ICAM)1 (CD54) (19), were undertaken. Here, CD276 is linked to neoplasm.