Among the NSCLC patients, both the squamous patients (HR (95%CI) = 0.67, (0.54, 0.82); p < 0.001) and non-squamous patients (0.69, (0.60, 0.79); p < 0.001) had more extended OS when compared with non-PD-1/PD-L1 therapy. The gene discussed is CD274; the disease is non-small cell lung carcinoma.