CISH and neoplasm: For example, hERG1 potassium channels have been shown to drive PDAC tumor malignancy [69], the neurotransmitter GABA was identified as a promising agent for the prevention of PDAC in individuals at risk due to chronic alcohol consumption [70], the transient receptor potential melastatin-related 7 channel was found to regulate tumor migration [71], the store-operated calcium channels (SOCs) were shown to contribute to PDAC apoptosis resistance [72] while the P2×7 receptor regulates cell survival, migration and invasion [73].