CXCL1 (chemokine with C-X-C motif ligand 1) is a member of the CXC chemokine family and promotes neoplastic transformation, tumorigenesis, and angiogenesis in breast, lung, pancreatic, colorectal, bladder, and prostate cancer, as well as in melanoma, by binding specifically to CXCR2 [4–9]. The gene discussed is CXCL1; the disease is prostate cancer.