Our data showed that the mRNA expression of Drp1 was positively correlated with the expression of cyclin D1 and cyclin E1 and negatively correlated with p21 (Figure 1D), suggesting that Drp1-mediated mitochondrial fission may play an important role in the regulation of cell cycle progression in HCC cells. The gene discussed is CDKN1A; the disease is hepatocellular carcinoma.