TP53 and cancer: Reports on the anti-cancer efficacy of QC on cancer cell lines suggests that it causes apoptosis by arresting the cell cycle in the S-phase via inhibition of the topoisomerase activity, induction of p53 and p21 [29, 30] and inhibition of NF-kβ and Wnt-TCF signaling through adenomatous polyposis coli (APC) gene [31].