TP53 and cancer: The diaryl trifluorothiazoline compound 1a, hereafter referred to as fluorizoline (Figure 1A), was selected as the best apoptosis inductor in a wide range of cancer cell lines from different tissue origin, including hematopoietic cell lines, and with different p53 status, proving that fluorizoline exerts its anti-tumor action in a p53-independent manner [12].