ERBB2 and gastric cancer: As previously reported, HER-2 overexpression or amplification was more common in patients with intestinal histology compared with those with diffuse histology (31.8 % vs. 6.1%) and in gastroesophageal junction cancer than in gastric cancer (32.2% vs. 21.4%), suggesting a different etiology and pathogenesis between proximal and distal gastric cancers [29].