ERBB2 and neoplasm: The effect of HER2-targeted therapies on two of these PDXs was assessed: single agent HER2-targeted therapy (with either trastuzumab, neratinib, or lapatinib) delayed the growth of these PDXs, while dual HER2-targeted therapy (with either trastuzumab plus neratinib or trastuzumab plus lapatinib) produced durable tumor regression [83].