ERBB2 and gastric cancer: Meanwhile, novel HER-2 inhibitors are also being studied in gastric cancer: lapatinib ditosylate, a dual anti-EGFR and anti-HER-2 tyrosine kinase inhibitor, was firstly tested in the TRIO-013/LOGiC trial designed to evaluate the efficacy and safety of the oral inhibitor in combination with capecitabine and oxaliplatin as first-line treatment of advanced or metastatic HER2-positive esophagogastric cancer.