MACC1 and colorectal carcinoma: Meanwhile, a tight association was also observed between MACC1 expression and CRC patient prognosis across various geographic regions; the pooled HR was 2.133 (95% CI = 1.382-3.292, P = 0.001) from Asia, and HR was characterized as 3.921 (95% CI = 2.497-6.155, P = 0.000) from non-Asian countries.