The decreased expression of RORα and RORγ during progression of melanocytic lesions and the significant reduction of their expression in most advanced primary melanomas (Breslow thickness >2mm, Clark level III-V, pT3-4, pN1-3, overall stage II-IV) and melanoma metastases suggest that reduced or lack of RORα and RORγ expression or defects in the ROR pathways could promote tumor progression. Here, LINC-ROR is linked to melanoma.