Detailed analysis of melanoma patients stratified according to the level of nuclear RORα expression revealed longer OS in patients with high (median survival 896.1 days) expression of the receptor in comparison to those that lacked nuclear stain (median survival 618.3 days) (χ2 = 7.420, P = 0.0064, Figure 13A, Table 2). This evidence concerns the gene RORA and melanoma.