We also tested the correlation between melanin pigmentation and RORα and RORγ expression in primary melanoma tumors (Figure 4A–4B), and have found that its nuclear immunoreactivity was inversely correlated with high melanin content (r=−0.2920, P=0.0052 and r=−0.2109, p=0.0399, respectively). The gene discussed is RORC; the disease is melanoma.