ADAMTS1 and cancer: For ADAMTS family members, metalloproteinase-related (ADAMTS1, 9) or angiogenesis-associated (ADAMTS1, 13) activity contributes to tumor development and progression [7–9], although some ADAMTSs inhibit or suppress cancer through metalloproteinase- or angiogenesis-independent activity (ADAMTS2, 12) [10, 11].