However, studies have suggested that the tumor-suppressive effects of ADAMTSs are linked to the deactivation of proliferation or invasion pathways, including inhibition of the ERK pathway by ADAMTS8 [13], ADAMTS12 [31], and ADAMTS15 [32]; and of the AKT/mTOR pathway by ADAMTS9 [14]. The gene discussed is ADAMTS15; the disease is neoplasm.