ACKR3 and neoplasm: As shown in Figures 1A-1F and Supplementary Figures S1A-S1F, which were derived from Beijing and Shanghai cohorts respectively, staining ranks of CXCL12 and CXCR7 in tumor tissues were statistically higher than those in non-tumor ones (P<0.001 and <0.001 for CXCL12; P=0.021 and =0.008 for CXCR7; Mann-Whitney U-test).