Surprisingly, the authors failed to discover changes in Akt (Figure 2C) and a large pool of proteins that were reported to be associated with CXCR7 in cancer (Supplementary Figure S4), but showed those in phosphorylation of mTOR, 4EBP1 and P70S6K (Figure 2C), indicating that mTOR activation might be involved in CXCR7-mediated migration and invasion in PC. The gene discussed is ACKR3; the disease is pachyonychia congenita.