The studies show that GRP-R expression is increased in atypical hyperplasia (mouse prostatic intraepithelial neoplasia PIN lesion) and mouse NEPC, including in the metastatic lesions to the liver; while, AR expression is decreased in PIN lesions and almost undetectable in mNEPC (Figure 6B). The gene discussed is GRPR; the disease is prostate intraepithelial neoplasia.