While Qiu et al. [63, 64] did not expose their Nucks1−/− mice to DNA damaging agents and did not investigate the direct phenotypic consequences of persistent or mis-repaired DNA damage in these mice, persistent and repetitive DNA damage has been proposed to alter insulin-IGF1 signaling, thereby contributing to diabetes and other age-associated metabolic disorders [5]. This evidence concerns the gene IGF1 and metabolic disease.