TP53 and neoplasm: We speculate that, within a subset of IR-induced TLs in Trp53+/− Nucks1+/− mice, increased expression of Nucks1/NUCKS1 may be associated with a selective advantage during tumor initiation and development, enabling early neoplastic cells to overcome replication stress during lymphomagenesis (Figure 9), thereby limiting DSBs resulting from collapsed replication forks [60, 61].