We speculate that partial NUCKS1 deficiency may lead to the accelerated loss of the Trp53 wild type allele in TLs from Trp53+/− Nucks1+/− mice, that compared to TLs from Trp53+/− mice arise at an earlier stage during T-cell development (i.e. show increased DN T-cell populations), predominate in Tcrb mono- and bi-clonality, and show relatively higher fractions of Igh- than of Tcra/d-associated translocation events, suggestive of their overall dependency on fewer genetic changes for tumor formation. This evidence concerns the gene NUCKS1 and neoplasm.